TRAIL Induces Nuclear Translocation and Chromatin Localization of TRAIL Death Receptors

Glucose Deprivation Induces ATF4-Mediated Apoptosis through TRAIL Death Receptors

Metabolic stress occurs frequently in tumors and in normal tissues undergoing transient ischemia. Nutrient deprivation triggers, among many potential cell death-inducing pathways, an endoplasmic reticulum (ER) stress response with the induction of the integrated stress response transcription factor ATF4. However, how this results in cell death remains unknown. Here we show that glucose deprivat...

TRAIL & TRAIL Receptors

TRAIL and its receptors Cell death

More than 20 years ago, phage λ geneticists identified certain mutations, termed Chi (χ), which increase the frequency of recombination in their vicinity (reviewed in [1]). A large body of experiments in phage λ and Escherichia coli established a number of properties of χ-dependent stimulation of recombination (Figure 1). The effect occurs on linear molecules, requiring a specific orientation b...

Expression of TRAIL and TRAIL death receptors in stage III non-small cell lung cancer tumors.

PURPOSE Several in vitro studies have shown that non-small cell lung cancer (NSCLC) cell lines are sensitive to apoptosis induction by the recombinant human (rh) tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death ligand, indicating that rhTRAIL might become an attractive molecule for treatment of NSCLCs. To investigate the therapeutic potential of rhTRAIL, the expression of T...

The Combination of TRAIL Treatment and Cancer Cell Selective Expression of TRAIL-Death Receptor DR4 Induces Cell Death in TRAIL-Resistant Cancer Cells

The human telomerase reverse transcriptase (hTERT) promoter can be used for the tumor-specific expression of transgenes in order to induce selective cancer cell death. The hTERT core promoter is active in cancer cells but not in normal cells. To examine whether the combination of TNF-related apoptosis inducing ligand (TRAIL) treatment and cancer cell-selective expression of the TRAIL-death rece...